There's a pregnancy registry for women who take diazepam tablets throughout pregnancy. The purpose of the registry is to gather information regarding the well being of you and your child.
Valium may possibly generate physical dependence from continued therapy. Actual physical dependence can be a state that develops on account of physiological adaptation in reaction to recurring drug use, manifested by withdrawal indicators and symptoms right after abrupt discontinuation or even a significant dose reduction of the drug. Abrupt discontinuation or fast dosage reduction of benzodiazepines or administration of flumazenil, a benzodiazepine antagonist, could precipitate acute withdrawal reactions, which include seizures, which might be life-threatening.
Concomitant use of benzodiazepines and opioids may well bring about profound sedation, respiratory depression, coma, and Demise. Reserve concomitant prescribing of those drugs in patients for whom alternative treatment alternatives are inadequate.
Diazepam is sometimes used with other medications to treat muscle spasms and stiffness, or seizures.
Oral diazepam tablets could possibly be used adjunctively in convulsive Problems, even though it hasn't proved useful as the only therapy. Diazepam is accessible in generic form.
Death is much more frequently involved with polysubstance use (Specially benzodiazepines with other CNS depressants including opioids and alcohol).
Diazepam and other benzodiazepines act by improving the effects of gamma-aminobutyric acid (GABA) from the brain. GABA can be a neurotransmitter (a chemical that nerve cells use to speak with Just about every other) that inhibits activity while in the brain.
Will not get started or stop seizure medication in the course of pregnancy without your medical doctor's advice. Diazepam might damage an unborn newborn, but having a seizure in the course of pregnancy could damage both equally mother and toddler. Blocking seizures may perhaps outweigh these threats. Convey to your medical doctor straight away should you become pregnant.
Equally Valium and generic diazepam could potentially cause unexpected changes in mental well being, which includes suicidal views. Call your Health care service provider instantly in the event you or even a cherished a person is taking diazepam and experience elevated irritability, aggression, panic assaults, or depression.
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Take the medication as soon as you could, but skip the missed dose if it is almost time for your personal following dose. Don't take two doses at one time.
Diazepam passes into breast milk. Breastfeeding is therefore not advised in patients receiving Valium.
Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 towards the Lively metabolite N-desmethyldiazepam, and it is hydroxylated by CYP3A4 on the Energetic metabolite temazepam.
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